Applications of Rotigotine API

Rotigotine is a non-ergot dopamine receptor agonist that is used in the treatment of Parkinson's disease and restless legs syndrome. Some key applications where rotigotine active pharmaceutical ingredient (API) has proven efficacy include:

Early Stage Parkinson's Disease

Rotigotine is approved for treatment of early stage Parkinson's disease. It helps reduce symptoms like tremor, rigidity, and slowness of movement by stimulating dopamine receptors. Rotigotine patches allow steady plasma levels for 24-hour symptom control.

Advanced Parkinson's Disease

In more advanced Parkinson's disease, rotigotine is often used as an adjunct to levodopa therapy to further improve motor symptoms when levodopa effects wear off (end of dose deterioration).

Restless Legs Syndrome

Rotigotine transdermal patches are approved for moderate-to-severe primary restless legs syndrome. Patch application before bedtime provides steady dopaminergic effects and reduces nighttime symptoms of RLS.

Autonomic Dysfunction

Some clinical evidence suggests rotigotine factory may help control autonomic symptoms associated with Parkinson’s disease like orthostatic hypotension, sweating, and bladder dysfunction based on effects on sympathetic nervous function.

Nocturia Treatment

The 24-hour coverage of rotigotine makes it suitable for treating nocturia, or excessive nighttime urination, in Parkinson’s patients by maintaining nighttime control of motor symptoms that interfere with sleep and lead to frequent urination.

Bipolar Depression

Adjunct rotigotine is being studied in clinical trials for improving depressive symptoms associated with bipolar I and II disorder by augmenting dopamine signaling.

Fibromyalgia

Early research indicates rotigotine patches may improve pain, fatigue, sleep and cognitive issues in fibromyalgia patients, possibly by correcting dopamine signaling pathway dysfunction.

Dosage Forms

Rotigotine is available as 1mg/24 hours, 2mg/24 hours, 3mg/24 hours, 4mg/24 hours, 6mg/24 hours, and 8mg/24 hours transdermal patches for once-daily administration to reach optimal dosing.

As a leading global rotigotine factory, we provide high purity rotigotine to support its growing use in Parkinson’s therapy and continued research into new indications.