Oligonucleotide Synthesis Market Overview
Oligonucleotides represent one of the fastest growing segments of the pharmaceutical industry. This can be attributed to the rapid pace of innovation in this field, driven by the need for effective and personalized pharmacological interventions.
The global Oligonucleotide Synthesis Market size is estimated to be worth $ 4.8 billion in 2024 and is expected to grow at compounded annual growth rate (CAGR) of 9.9% during the forecast period 2024-2035.
There is a significant rise in the interest of stakeholders in oligonucleotide synthesis segment; this can be validated by the increase in partnership and funding activity within this domain.
Oligonucleotide Synthesis Market Segmentation
Oligonucleotide Synthesis Market focuses on Application Area (Research and Diagnostics, and Therapeutics), Type of Product Synthesized (Active Pharmaceutical Ingredients and Finished Dosage Forms), Type of Oligonucleotide Synthesized (Antisense, DNA, siRNA and Other Oligonucleotides), Scale of Operation (Clinical and Commercial), Therapeutic Area (Cardiovascular Disorders, Genetic Disorders, Liver Disorders, Rare Diseases, and Other Disorders), End-Users (Pharmaceutical / Biopharmaceutical Companies, Academic and Research Institutes, and Hospitals), Company Size (Small, Mid-sized, and Large and Very Large) and Key Geographical Regions (North America, Europe, Asia-Pacific and Rest of the World).
Further, the growing demand for oligonucleotides has compelled the players engaged in this domain to expand their existing capabilities / capacities in order to accommodate the future needs of their clients. In addition, innovation in this field, coupled to the development of novel fermentation technologies, has further expeditated the growth of oligonucleotide synthesis segment.
In order to accommodate their growing businesses, contract manufacturers are heavily investing in either expanding their existing facilities / capabilities or construct / acquire new facilities in other geographies. Close to 60 expansion initiatives have been undertaken in the oligonucleotide synthesis industry, during the period 2015-2023, majority of which were reported during the period 2021. This can be attributed to the indubitably rising demand for oligonucleotides in the COVID-19 pandemic.
Moreover, 33% of the companies in this domain have expanded their facilities for the synthesis of oligonucleotides at clinical scale only, followed by 29% of those undertaking such initiatives for the production of oligonucleotides at preclinical, clinical and commercial scales of operation; notable examples of such service providers (in alphabetical order) include Dalton Pharma Services, EUROAPI, Nitto Avecia and WuXi STA. To keep pace with the growing demand for oligonucleotides, companies have made elaborate investments to expand their existing capacities and capabilities; this trend is most pronounced in the US and China.
Owing to several factors, including globalization and introduction of political and regulatory
reforms, advanced contract manufacturing services for oligonucleotides are no longer confined to the developed geographies alone. Currently, several players in emerging geographies, such as those based in China, India, Asia-Pacific and Latin America, offer high quality contract manufacturing services for oligonucleotides, along with providing lucrative cost benefits.
Oligonucleotide Synthesis Market Leading Companies
Examples of key oligonucleotide synthesis market companies include Agilent Technologies, Ajinomoto Bio-Pharma Services, CordenPharma, Creative Biolabs, Ella Biotech, Eurofins Genomics, Future synthesis, Integrated DNA Technologies, Kaneka Eurogentec, LGC Biosearch Technologies, Microsynth, Nitto Avecia, Merck, Ribo Biotechnology, STA Pharmaceutical, Sumitomo Chemical, Thermo Fisher Scientific, TriLink Biotechnologies.
Maximum oligonucleotide synthesis capacity is installed in the facilities located in North America this can be attributed to the inherent technological advancements and well-established regulatory landscape of this region. This is followed by oligonucleotide synthesis capacity installed in facilities located in Asia-Pacific and rest of the world owing to the low cost of labor and other resources, players based in this region have managed to establish production facilities with high capacity. The global, installed oligonucleotide synthesis capacity is spread across various geographies and more than 75% of the total capacity is installed at the facilities owned by large and very large players.
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